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GHRH (Growth Hormone Releasing Hormones) such as CJC-1295 and the tesamorelin activate the GHRH-R receptor of the pituitary gland and initiate the pulsatile release of GH

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In some cases, you may notice improvements within a few weeks, while others may take longer

The specific mechanism may also be by activating VEGF-A / VEGFR1 -mediated AKT and p38/MAPK signaling pathways to upregulate downstream eNOS expression, which may increase the NO product synthesis, thus promote angiogenesis of gastric mucosa and also interact with endoplasmic reticulum (ER) stress

Sosne G, Kleinman HK